TrendPulse Logo

Autonomous closed-loop framework for reproducible perovskite solar cells | Nature

Source: NatureView Original
scienceApril 14, 2026

Subjects

- Energy

- Solar cells

Abstract

The commercialization of perovskite solar cells is bottlenecked by inefficient, trial-and-error approaches reliant on human expertise in both material discovery and device fabrication (1-3). Here, we introduce an autonomous closed-loop framework that integrates machine learning (ML)-driven material discovery with an automated manufacturing platform. The system employs active learning and quantum modeling to rapidly identify high-performance molecules, while the platform uses Bayesian optimization and symbolic regression in a feedback loop to continuously refine the fabrication process. This integrated approach enabled the discovery of a passivation molecule, 5-(aminomethyl)nicotinonitrile hydroiodide (5ANI), which yielded 0.05 cm² solar cells with a power conversion efficiency (PCE) of 27.22% (certified maximum power point tracking (MPPT) efficiency of 27.18%) and 21.4 cm² mini-modules with a PCE of 23.49%. Moreover, the devices exhibited long-term operational stability, retaining 98.7% of their initial efficiency after 1,200 hours of continuous operation under the ISOS-L-1I protocol. Crucially, the automated platform achieved an efficiency reproducibility nearly 5 times that of manual fabrication. This work establishes an automated closed-loop system that synergizes ML-powered discovery with the high-fidelity data from automated manufacturing, setting a benchmark for autonomous discovery and manufacturing in photovoltaics and materials.

Access through your institution

Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

$32.99 / 30 days

cancel any time

Learn more

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Learn more

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Author information

Author notes- Xianglang Sun

(孙祥浪)

Present address: Hubei Key Laboratory of Material Chemistry and Service Failure, Key Laboratory for Material Chemistry of Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, P. R. China

- These authors contributed equally: Danpeng Gao, Shuaihua Lu, Chunlei Zhang, Ning Wang, Zexin Yu, Xianglang Sun

Authors and Affiliations

- Department of Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China

Danpeng Gao

(高丹鹏), Chunlei Zhang

(张春雷), Ning Wang

(王宁), Zexin Yu

(余泽鑫), Xianglang Sun

(孙祥浪), Francesco Vanin, Liangchen Qian

(钱良辰), Bo Li

(李博) & Zonglong Zhu

(朱宗龙)

- Department of Materials Science & Engineering, City University of Hong Kong, Kowloon, Hong Kong, China

Shuaihua Lu

(陆帅华), Nan Li

(李楠) & Xiao Cheng Zeng

(曾晓成)

- Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK

Rebecca Martin & Samuel D. Stranks

- Department of Chemistry, Imperial College London; MSRH Building, White City Campus, London, UK

Francesco Vanin, Nicholas Long & Nicola Gasparini

- Institute of Materials for Electronics and Energy Technology (i-MEET), Department of Materials Science and Engineering, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany

Larry Lüer & Christoph Joseph Brabec

- School of Materials Science and Engineering, Central South University, Changsha, P. R. China

Bo Li

(李博)

- Electronic Engineering Department, The Chinese University of Hong Kong, New Territories, Hong Kong, China

Martin Stolterfoht

- Department of Computer Science, City University of Hong Kong, Kowloon, Hong Kong, China

Junhui Hou

(侯军辉)

- Department of Applied Physics, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China

Jun Yin

(殷骏)

- Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China

Yen-Hung Lin

(林彥宏)

- Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

Haipeng Lu

(吕海鹏)

- Helmholtz-Institute Erlangen-Nürnberg for Renewable Energy (HI ERN), Forschungszentrum Jülich, Erlangen, Germany

Christoph Joseph Brabec

- Energy Campus Nürnberg (EnCN), Fürtherstrasse 250, Nürnberg, Germany

Christoph Joseph Brabec

- Institute of Materials Data Science and Informatics (IMD-3), Forschungszentrum Jülich, Jülich, Germany

Christoph Joseph Brabec

- Hong Kong Institute for Clean Energy, City University of Hong Kong, Kowloon, Hong Kong, China

Zonglong Zhu

(朱宗龙)

Authors- Danpeng Gao

(高丹鹏)View author publications

Search author on:PubMed Google Scholar

- Shuaihua Lu

(陆帅华)View author publications

Search author on:PubMed Google Scholar

- Chunlei Zhang

(张春雷)V

Autonomous closed-loop framework for reproducible perovskite solar cells | Nature | TrendPulse