Correction Issued for Nature Study on Pig-to-Human Kidney Xenotransplantation

A formal correction has been issued for a significant study published in Nature on November 13, 2025, concerning the physiology and immunology of pig-to-human decedent kidney xenotransplantation. The original research, conducted by a multi-institutional team led by experts from NYU Langone and Columbia University, explores the critical challenges of cross-species organ transplantation.

The correction addresses specific data discrepancies found within Extended Data Fig. 8 of the original publication. The authors identified errors in the reported frequencies of immune cell populations in graph iv, as well as a misstated percentage for hCD45 levels in graph iii. The updated figures provide corrected values, notably shifting the reported distribution of T-cell subsets and human leukocyte markers to ensure the accuracy of the immunological findings.

While these adjustments are technical in nature, they are vital for maintaining the integrity of preclinical and translational research. Accurate reporting of immune cell profiles is essential for understanding how human systems interact with genetically modified porcine organs. By rectifying these figures, the researchers ensure that the scientific community has a precise baseline for evaluating the safety and efficacy of xenotransplantation protocols.

This study remains a cornerstone of current efforts to address the global organ shortage through xenotransplantation. The correction underscores the rigorous peer-review and post-publication scrutiny processes that define high-impact scientific literature, ensuring that data-driven conclusions regarding transplant immunology remain reliable for future clinical development.