Close Banner

Integrative Health

Scientists Says Our Brain’s Reward System Chases This (Not Dopamine)

Author: Sela Breen

March 24, 2026

Assistant Health Editor

By Sela Breen

Assistant Health Editor

Sela Breen is the Assistant Health Editor at mindbodygreen. She is a graduate of the Medill School of Journalism at Northwestern University, where she studied journalism, international studies, and theatre.

Image by Santi Nunez / Stocksy

March 24, 2026

Dopamine has long been a buzzword for those thinking about mood, happiness, and attention. But what if dopamine isn't the "feel-good" chemical we've been told it is?

A new study suggests we may have been thinking about dopamine all wrong. Researchers at Hebrew University have discovered that the brain's reward system is fundamentally about metabolic energy1, not dopamine signaling. Their new framework could change how we understand motivation, addiction, and even depression.

A quick primer on the traditional dopamine model

For decades, the dominant view in neuroscience has been that dopamine is the brain's "reward chemical." When you eat something delicious, accomplish a goal, or experience something pleasurable, dopamine floods your brain's reward circuits, creating a satisfying feeling. Opioids (the brain's endorphins) would then create the pleasure you feel when you are rewarded.

This model has shaped how we understand many brain functions and mental health conditions. Under this model, addiction stems from hijacked dopamine pathways, motivation is equated with dopamine-driven goal pursuit, and depression is caused by depleted dopamine levels.

However, research has consistently shown that dopamine doesn't always correlate with "liking" something. You can have high dopamine and still not enjoy an experience. You can desperately want something without actually finding it pleasurable when you get it.

This disconnect is what led researchers Matan Cohen and Shir Atzil to dig deeper, and ask if dopamine is really responsible for encoding reward in the first place.

The new framework is all about metabolic energy

This new study proposes that dopamine and opioids don't create feelings of motivation and pleasure directly. Instead, they're physiological regulators, and the metabolic consequences of that regulation are what we actually experience as reward.

In this model, you can think of dopamine as your body's gas pedal. Dopamine upregulates energy by increasing your heart rate, mobilizing glucose, preparing your body for action. Opioids, on the other hand, are the brake. They downregulate the body by promoting rest, recovery, and conservation.

In this framework, the motivated, driven feeling once thought to be caused by dopamine actually emerges from your brain anticipating energy will be available. Your dopamine system revs up to prepare you to pursue goals and complete tasks.

Then, when your body shifts into energy-conservation mode, the satisfied, pleasurable feeling emerges. This is the opioid system kicking in, signaling that you've accomplished what you needed and can now rest.

What's exciting about this framework is that it is measurable in a way the traditional dopamine model is not. Pleasure is a subjective experience, but metabolic energy markers like glucose levels, lactate, and ATP can be tracked objectively, opening the door for new research.

What this means for motivation and pleasure

So what gives you motivation to pursue certain things? According to this model, it's because your brain is anticipating energy availability. When you're drawn to food, social connection, or achievement, it's your brain saying that these activities will provide resources.

Satisfaction is your body shifting into conservation mode. You've obtained what you needed, and now your system can downregulate. Your heart rate slows, stress hormones decrease, and you experience that warm sense of relief and satisfaction.

This explains phenomena like the "runner's high." It's not just about endorphins flooding your brain; it's about the metabolic shift that occurs when intense energy expenditure transitions to recovery. Your opioid system activates, signaling that the energy demand is over.

This also explains why some rewards feel empty. If you're pursuing something that doesn't actually serve your metabolic needs, or if your system becomes dysregulated and the anticipated energy payoff never materializes, your left wanting more without ever experiencing that feeling of satisfaction.

Implications for addiction and depression

This framework offers a fresh lens on mental health conditions that have long been attributed to dopamine dysfunction.

With this perspective, we can see how addiction isn't just about "hijacked" dopamine pathways. Addictive substances and behaviors may disrupt energy regulation, leading to a combination of intense energy mobilization and extreme crashes that never allow the system to achieve satisfaction and balance.

Depression, and the in